Necrotizing Enterocolitis Pathophysiology
نویسندگان
چکیده
منابع مشابه
The Pathophysiology of Necrotizing Enterocolitis
Introduction Despite many years of clinical observation and experimental investigation, the pathogenesis of neonatal enterocolitis (NEC) remains elusive. The multifactorial theory suggests that four key risk factors—prematurity, formula feeding, intestinal ischemia, and bacterial colonization—are important prerequisites to the initiation of intestinal injury in neonates (Figure). Current hypoth...
متن کاملNew Frontiers of Necrotizing Enterocolitis: From Pathophysiology to Treatment
Necrotizing enterocolitis [NEC] is an inflammatory disease of intestine largely occuring in preterm infants with a wide range of damage from minimal injury limited to mucosa to extensive necrosis of bowel wall and perforation. Despite advancements in neonatal care, mortality remains high [30% 50%] and controversy still persists with regards to the most appropriate management of neonates with ne...
متن کاملNecrotizing enterocolitis report of 20 cases
Necrotizing enterocolitis is a disease of unknown origin. Epidemiological observations emphasize the potential roles of infection, enteric feeding and local vascular compromise of the Gastrointestinal tract in the pathogenesis of this disease. Clinical findings include signs of sepsis , plus abdominal distention , vomiting, bloody stool and occasionally , signs of intestinal perforation and pe...
متن کاملNecrotizing enterocolitis
During the 3 years 1972-74, 17 infants were treated for necrotizing enterocolitis (NEC) in the Neonatal Unit at University College Hospital. The incidence of the illness was 0 2% of live births in the hospital and 2.7% of those referred from elsewhere. The mean birthweight of the affected infants was 1832 g (range 878-3850 g) and mean gestational age 33 weeks (range 28-40 weeks). The illness wa...
متن کاملNecrotizing enterocolitis.
Necrotizing enterocolitis (NEC) is an important cause of neonatal morbidity and mortality. During the last few years, there was an increase in the incidence of this disease, associated with a better knowledge of NEC, and an increase in survival rate, associated with the development, even from a technological point of view, of neonatal intensive care units. In this study, the authors first perfo...
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ژورنال
عنوان ژورنال: Clinics in Perinatology
سال: 2019
ISSN: 0095-5108
DOI: 10.1016/j.clp.2018.10.003